Siezen Christine L E, Bont Louis, Hodemaekers Hennie M, Ermers Marieke J, Doornbos Gerda, Van't Slot Ruben, Wijmenga Ciska, Houwelingen Hans C van, Kimpen Jan L L, Kimman Tjeerd G, Hoebee Barbara, Janssen Riny
Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Pediatr Infect Dis J. 2009 Apr;28(4):333-5. doi: 10.1097/INF.0b013e31818e2aa9.
Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
早产是严重呼吸道合胞病毒细支气管炎的一个风险因素。我们发现，先天免疫基因（IFNA13、IFNAR2、STAT2、IL27、NFKBIA、C3、IL1RN、TLR5）、先天和适应性免疫（IFNG）以及气道重塑基因（ADAM33和TGFBR1）中的遗传因素，对肺部发育不全的早产儿疾病易感性的影响程度，与足月儿不同。
