Kagemann Larry, Ishikawa Hiroshi, Wollstein Gadi, Gabriele Michelle, Schuman Joel S
UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Opt Express. 2009 Mar 2;17(5):4208-20. doi: 10.1364/oe.17.004208.
Optical coherence tomography has allowed unprecedented visualization of ocular structures, but the identity of some visible objects within slices remains unknown. This study reconstructs a number of those objects in 3D space, allowing their identification by observation of their 3D morphology. In the case mottling deep within image slices through the optic disc, C-mode imaging provided visualization of the appearance and distribution of laminar pores. In the case of white spots and streaks sometimes observed in image slices through the cornea, C-mode imaging contoured to the path of those white spots allowed their visual identification as nerves extending radially into the cornea from the limbus. White spots observed in ultra-high resolution retinal image slices were identified as blood within retinal capillaries. C-mode contour-corrected imaging of three dimensional structures provided the identification of previously unidentified structures visible in cross-sectional image slices.
光学相干断层扫描技术使人们能够以前所未有的方式观察眼部结构，但切片内一些可见物体的身份仍然未知。本研究在三维空间中重建了其中一些物体，通过观察它们的三维形态来进行识别。在通过视盘的图像切片深处出现斑点的情况下，C模式成像显示了层状孔隙的外观和分布。在通过角膜的图像切片中有时观察到的白色斑点和条纹的情况下，对这些白色斑点路径进行轮廓描绘的C模式成像使它们能够被视觉识别为从角膜缘径向延伸到角膜的神经。在超高分辨率视网膜图像切片中观察到的白色斑点被识别为视网膜毛细血管内的血液。对三维结构进行C模式轮廓校正成像，能够识别出在横截面图像切片中可见但以前未被识别的结构。
