Keijsers Ruth G, Verzijlbergen Fred J, Oyen Wim J, van den Bosch Jules M, Ruven Henk J, van Velzen-Blad Heleen, Grutters Jan C
Department of Nuclear Medicine, St. Antonius Hospital Nieuwegein, P.O. Box 2500, 3430 EM, Nieuwegein, The Netherlands.
Eur J Nucl Med Mol Imaging. 2009 Jul;36(7):1131-7. doi: 10.1007/s00259-009-1097-x. Epub 2009 Mar 4.
Angiotensin-converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) are serological markers, widely used for determining sarcoidosis activity. (18)F-FDG PET has proven to be a sensitive technique in the imaging of sarcoidosis. The aim of this study was to determine sensitivity of (18)F-FDG PET, genotype-corrected ACE and sIL-2R in active sarcoidosis as well as their correlation.
This retrospective study included 36 newly diagnosed, symptomatic sarcoidosis patients. ACE and sIL-2R levels were simultaneously obtained within 4 weeks of (18)F-FDG PET. ACE was corrected for genotype and expressed as Z-score. (18)F-FDG PET was visually evaluated and scored as positive or negative. Maximum and average standardized uptake values (SUV(max) and SUV(avg)) were compared with ACE and sIL-2R.
(18)F-FDG PET was found positive in 34 of 36 patients (94%). Thirteen patients (36%) showed an increased ACE with the highest sensitivity found in patients with the I/I genotype (67%). Seventeen patients (47%) showed an increased sIL-2R. No correlation was found between SUV and ACE or sIL-2R. Increased ACE and sIL-2R correlated with a positive (18)F-FDG PET in 12 patients (92%) and 16 patients (94%), respectively.
(18)F-FDG PET is a very sensitive technique to assess active sarcoidosis, in contrast with ACE and sIL-2R, suggesting a pivotal role for (18)F-FDG PET in future sarcoidosis assessment.
血管紧张素转换酶（ACE）和可溶性白细胞介素-2受体（sIL-2R）是血清学标志物，广泛用于确定结节病的活动情况。（18）F-FDG PET已被证明是结节病成像中的一种敏感技术。本研究的目的是确定（18）F-FDG PET、基因型校正后的ACE和sIL-2R在活动性结节病中的敏感性及其相关性。
这项回顾性研究纳入了36例新诊断的有症状结节病患者。在（18）F-FDG PET检查后4周内同时测定ACE和sIL-2R水平。对ACE进行基因型校正并表示为Z评分。对（18）F-FDG PET进行视觉评估并分为阳性或阴性。将最大和平均标准化摄取值（SUV（max）和SUV（avg））与ACE和sIL-2R进行比较。
36例患者中有34例（94%）（18）F-FDG PET呈阳性。13例患者（36%）ACE升高，其中I/I基因型患者的敏感性最高（67%）。17例患者（47%）sIL-2R升高。未发现SUV与ACE或sIL-2R之间存在相关性。ACE升高和sIL-2R升高分别与12例患者（92%）和16例患者（94%）的（18）F-FDG PET阳性相关。
与ACE和sIL-2R相比，（18）F-FDG PET是评估活动性结节病的一种非常敏感的技术，这表明（18）F-FDG PET在未来结节病评估中起关键作用。
