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膀胱癌:新的经尿道切除术技术

Bladder cancer: new TUR techniques.

作者信息

Wilby Daniel, Thomas Kay, Ray Eleanor, Chappell Barnaby, O'Brien Timothy

机构信息

Department of Urology, Southwark Wing, Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.

出版信息

World J Urol. 2009 Jun;27(3):309-12. doi: 10.1007/s00345-009-0398-9. Epub 2009 Mar 4.

Abstract

Transurethral resection of bladder tumours (TURBT) using a wire loop remains the gold-standard treatment for bladder tumours, but it is associated with unacceptably high early recurrence rates after first resection. Improvements to standard resection techniques and a range of optical and technological advances offer exciting possibilities for improving outcomes. Early second resection has been shown to reduce recurrence rates, and increase response to intravesical chemotherapy and/or immunotherapy. It should be considered in most high-risk non-muscle invasive cancers (T1; G3; multifocal) being managed by bladder conservation. Newer energy sources, such as laser, may facilitate day case management of bladder tumours using local anaesthesia in select groups of patients. The novel technique of photodynamic diagnosis improves tumour detection, and quality of resection, and is likely to become the standard for initial tumour management. The traditional 'incise and scatter' resection technique goes against all oncological surgical principles. En-bloc resection of tumours would be far preferable and demands further development and evaluation. The technique of TURBT needs to evolve to allow first-time clearance of disease and low recurrence rates.

摘要

使用金属丝圈套器经尿道膀胱肿瘤切除术(TURBT)仍是膀胱肿瘤的金标准治疗方法,但首次切除后其早期复发率高得令人难以接受。标准切除技术的改进以及一系列光学和技术进步为改善治疗效果提供了令人兴奋的可能性。早期二次切除已被证明可降低复发率,并提高对膀胱内化疗和/或免疫治疗的反应。对于大多数采用膀胱保留治疗的高危非肌层浸润性癌(T1;G3;多灶性),应考虑进行早期二次切除。新型能源,如激光,可能有助于在特定患者群体中使用局部麻醉对膀胱肿瘤进行日间手术管理。光动力诊断新技术可提高肿瘤检测率和切除质量,很可能成为初始肿瘤治疗的标准。传统的“切割与播散”切除技术违背了所有肿瘤外科原则。肿瘤整块切除更为可取,需要进一步发展和评估。TURBT技术需要不断发展,以实现首次疾病清除和低复发率。

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