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估算法国人群中结直肠癌监测的相关成本。

Estimating the cost related to surveillance of colorectal cancer in a French population.

作者信息

Lejeune Catherine, Binquet Christine, Bonnetain Franck, Mahboubi Amel, Abrahamowicz Michal, Moreau Thierry, Raikou Maria, Bedenne Laurent, Quantin Catherine, Bonithon-Kopp Claire

机构信息

Faculté de Médecine, Inserm U866, 7 Bd Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.

出版信息

Eur J Health Econ. 2009 Oct;10(4):409-19. doi: 10.1007/s10198-009-0144-7. Epub 2009 Mar 4.

Abstract

Little is known about costs related to the surveillance of patients that have undergone curative resection of colorectal cancer. The aim of this study was to calculate the observed surveillance costs for 385 patients followed-up over a 3-year period, to estimate surveillance costs if French guidelines are respected, and to identify the determinants related to surveillance costs to derive a global estimation for France, using a linear mixed model. The observed mean surveillance cost was 713. If French recommendations were strictly applied, the estimated mean cost would vary between 680 and 1,069 according to the frequency of abdominal ultrasound. The predicted determinants of cost were: age, recurrence, duration of surveillance since diagnosis, and adjuvant treatments. For France, the surveillance cost represented 4.4% of the cost of colorectal cancer management. The cost of surveillance should now be balanced with its effectiveness and compared with surveillance alternatives.

摘要

关于接受结直肠癌根治性切除术后患者的监测相关成本,我们了解得甚少。本研究的目的是计算385例患者在3年随访期内的实际监测成本,估算若遵循法国指南时的监测成本,并使用线性混合模型确定与监测成本相关的决定因素,从而得出法国的总体估算值。实际监测平均成本为713欧元。若严格应用法国的建议,根据腹部超声检查频率,估算的平均成本在680欧元至1069欧元之间。预测的成本决定因素为:年龄、复发情况、诊断后监测时长以及辅助治疗。对于法国而言,监测成本占结直肠癌治疗总成本的4.4%。现在,监测成本应与其有效性相权衡,并与其他监测方案进行比较。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6165/2820507/1a239918f075/halms369477f1.jpg

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