Johnsen John Inge, Kogner Per, Albihn Ami, Henriksson Marie Arsenian
Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Childhood Cancer Research Unit, Karolinska University Hospital, Stockholm, Sweden.
Apoptosis. 2009 Apr;14(4):424-38. doi: 10.1007/s10495-009-0325-y.
Medulloblastoma and neuroblastoma are malignant embryonal childhood tumours of the central and peripheral nervous systems, respectively, which often show poor clinical prognosis due to resistance to current chemotherapy. Both these tumours have deficient apoptotic machineries adopted from their respective progenitor cells. This review focuses on the specific background for tumour development, and highlights biological pathways that present potential targets for novel therapeutic approaches.
髓母细胞瘤和神经母细胞瘤分别是中枢神经系统和周围神经系统的恶性胚胎性儿童肿瘤，由于对当前化疗具有抗性，它们的临床预后往往较差。这两种肿瘤都具有从各自祖细胞继承而来的缺陷凋亡机制。本综述重点关注肿瘤发生的特定背景，并强调了那些为新型治疗方法提供潜在靶点的生物学途径。
