Marbet U A
Abteilung für Innere Medizin, Kantonsspital Uri.
Ther Umsch. 1991 Jul;48(7):508-14.
Intestinal side effects after antibiotic therapy are frequent. Mostly, harmless diarrhea disappears after cessation of therapy without inducing colitis; however, changing of the intestinal flora sometimes leads to colonization of the colon by toxin-producing strains of Clostridium difficile, inducing sometimes severe pseudomembranous colitis. A rapid correct diagnosis by anamnesis, clinical signs, endoscopical aspect and demonstration of toxin in the stool allows an efficient treatment. The therapeutic modalities, especially in recurrency, are delineated. In addition, the unusual and etiologically still unknown illness of penicillin-induced segmental hemorrhagic colitis will be discussed as well.
抗生素治疗后的肠道副作用很常见。大多数情况下，无害的腹泻在治疗停止后会消失，不会引发结肠炎；然而，肠道菌群的改变有时会导致产毒素艰难梭菌菌株在结肠定植，有时会引发严重的假膜性结肠炎。通过问诊、临床症状、内镜表现以及粪便中毒素的检测进行快速准确的诊断，有助于进行有效治疗。文中阐述了治疗方法，尤其是针对复发情况的治疗方法。此外，还将讨论青霉素诱导的节段性出血性结肠炎这种不常见且病因仍不明的疾病。
