Cooper B G, Veale D, Griffiths C J, Gibson G J
Department of Respiratory Medicine, Freeman Hospital, Newcastle upon Tyne.
Thorax. 1991 Aug;46(8):586-8. doi: 10.1136/thx.46.8.586.
The sensitivity and specificity of overnight recording of arterial oxygen saturation (SaO2) in routine clinical practice was evaluated in 41 subjects who were being investigated for possible sleep apnoea-hypopnoea syndrome. SaO2 was measured with an ear probe oximeter (Biox IIa) and chart recorder during an "acclimatisation" night immediately before a detailed polysomnographic study. The recordings were classified by two observers as positive, negative, or uninterpretable. Twelve of the 41 patients had the obstructive sleep apnoea syndrome when defined in terms of an apnoea-hypopnoea index greater than 15 events an hour on the second night. The sensitivity of nocturnal SaO2 on the acclimatisation night when the diagnostic criterion was an apnoea-hypopnoea index of greater than 5, greater than 15, and greater than 25/h was 60%, 75%, and 100% respectively. Corresponding values for specificity were 95%, 86%, and 80%. Oximetry alone therefore allowed recognition of a moderate or severe sleep apnoea syndrome. In routine practice an appreciable number of equivocal results is likely and repeat oximetry or more detailed polysomnography will then be required if clinical suspicion is high.
在41名因可能患有睡眠呼吸暂停低通气综合征而接受检查的受试者中，评估了常规临床实践中夜间记录动脉血氧饱和度（SaO2）的敏感性和特异性。在进行详细的多导睡眠图研究之前的“适应”夜间，使用耳探头血氧计（Biox IIa）和图表记录器测量SaO2。两位观察者将记录分为阳性、阴性或无法解读。根据第二晚每小时呼吸暂停低通气指数大于15次事件的定义，41例患者中有12例患有阻塞性睡眠呼吸暂停综合征。当诊断标准为呼吸暂停低通气指数大于5、大于15和大于25/小时时，适应夜间夜间SaO2的敏感性分别为60%、75%和100%。特异性的相应值分别为95%、86%和80%。因此，仅靠血氧测定法就能识别中度或重度睡眠呼吸暂停综合征。在常规实践中，可能会出现相当数量的模棱两可的结果，如果临床怀疑度高，则需要重复进行血氧测定或更详细的多导睡眠图检查。
