Joo Choun-Ki, Seomun Young
Laboratory of Ophthalmology and Visual Science, Korean Eye Tissue and Gene Bank related to Blindness, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Cell Adh Migr. 2008 Oct-Dec;2(4):252-3. doi: 10.4161/cam.2.4.6772. Epub 2008 Oct 11.
Cell migration during wound healing is a complex process that involves the expression of a number of growth factors and cytokines. One of these factors, transforming growth factor-beta (TGFbeta) controls many aspects of normal and pathological cell behavior. It induces migration of keratinocytes in wounded skin and of epithelial cells in damaged cornea. Furthermore, this TGFbeta-induced cell migration is correlated with the production of components of the extracellular matrix (ECM) proteins and expression of integrins and matrix metalloproteinases (MMPs). MMP digests ECMs and integrins during cell migration, but the mechanisms regulating their expression and the consequences of their induction remain unclear. It has been suggested that MMP-14 activates cellular signaling processes involved in the expression of MMPs and other molecules associated with cell migration. Because of the manifold effects of MMP-14, it is important to understand the roles of MMP-14 not only the cleavage of ECM but also in the activation of signaling pathways.
伤口愈合过程中的细胞迁移是一个复杂的过程，涉及多种生长因子和细胞因子的表达。其中一种因子，转化生长因子-β（TGFβ）控制着正常和病理细胞行为的许多方面。它诱导受伤皮肤中的角质形成细胞和受损角膜中的上皮细胞迁移。此外，这种TGFβ诱导的细胞迁移与细胞外基质（ECM）蛋白成分的产生以及整合素和基质金属蛋白酶（MMP）的表达相关。MMP在细胞迁移过程中消化ECM和整合素，但其表达调控机制及其诱导的后果仍不清楚。有人提出MMP-14激活参与MMP表达和与细胞迁移相关的其他分子表达的细胞信号传导过程。由于MMP-14具有多种作用，因此了解MMP-14的作用不仅在于ECM的裂解，还在于信号通路的激活，这一点很重要。
