伤口愈合过程中角质形成细胞再上皮化的细胞和分子层面
Cellular and molecular facets of keratinocyte reepithelization during wound healing.
作者信息
Santoro Massimo M, Gaudino Giovanni
机构信息
Department of Medical Sciences, University of Piemonte Orientale A. Avogadro, Via Solaroli 17, 28100 Novara, Italy.
出版信息
Exp Cell Res. 2005 Mar 10;304(1):274-86. doi: 10.1016/j.yexcr.2004.10.033. Epub 2004 Dec 8.
Cutaneous wound healing is a highly coordinated physiological process that rapidly and efficiently restores skin integrity. Reepithelization is a crucial step during wound healing, which involves migration and proliferation of keratinocytes to cover the denuded dermal surface. Recent advances in wound biology clarified the molecular pathways governing keratinocyte reepithelization at wound sites. These new findings point towards novel therapeutic targets and provide suitable methods to promote faster tissue regeneration in vivo.
皮肤伤口愈合是一个高度协调的生理过程，能快速且有效地恢复皮肤完整性。再上皮化是伤口愈合过程中的关键步骤，涉及角质形成细胞的迁移和增殖以覆盖裸露的真皮表面。伤口生物学的最新进展阐明了在伤口部位控制角质形成细胞再上皮化的分子途径。这些新发现指向了新的治疗靶点，并提供了促进体内更快组织再生的合适方法。
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