Zhang Shan, Guo Ayao, Wang Huan, Liu Jia, Dong Chenshuang, Ren Junyi, Wang Guiling
Key Laboratory of Cell Biology, Department of Cell Biology, Ministry of Public Health and Key Laboratory of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang, Liaoning 110122, China.
Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.
Genes Dis. 2023 Jul 3;11(2):861-873. doi: 10.1016/j.gendis.2023.05.010. eCollection 2024 Mar.
Microrchidia CW-type zinc finger 2 (MORC2) is a member of the MORC superfamily of nuclear proteins. Growing evidence has shown that MORC2 not only participates in gene transcription and chromatin remodeling but also plays a key in human disease and tumor development by regulating the expression of downstream oncogenes or tumor suppressors. The present review provides an updated overview of MORC2 in the aspect of cancer hallmark and therapeutic resistance and summarizes its upstream regulators and downstream target genes. This systematic review may provide a favorable theoretical basis for emerging players of MORC2 in tumor development and new insight into the potential clinical application of basic science discoveries in the future.
微睾 CW 型锌指蛋白 2（MORC2）是核蛋白 MORC 超家族的成员。越来越多的证据表明，MORC2 不仅参与基因转录和染色质重塑，还通过调节下游癌基因或肿瘤抑制因子的表达在人类疾病和肿瘤发展中起关键作用。本综述提供了关于 MORC2 在癌症特征和治疗耐药性方面的最新概述，并总结了其上游调节因子和下游靶基因。这一系统综述可能为 MORC2 在肿瘤发展中的新作用提供有利的理论基础，并为未来基础科学发现的潜在临床应用提供新的见解。
