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新生儿先天性牙龈瘤,文献综述及病例报告

Congenital epulis in the newborn, review of the literature and a case report.

作者信息

Eghbalian Fatemeh, Monsef Alireza

机构信息

Hamadan University of Medical Sciences.

出版信息

J Pediatr Hematol Oncol. 2009 Mar;31(3):198-9. doi: 10.1097/MPH.0b013e31818ab2f7.

Abstract

Congenital epulis (CE) is a rare tumor of the newborn, also known as granular cell tumor or congenital gingival granular cell tumor because of its histologic features. Neumann first described CE in 1871. Epulis is seen only in the newborn and is a different entity from other granular cell tumors. CE has a female predilection with 8:1 ratio. Epulis is most frequently located on the anterior maxillary alveolar ridge and usually occurs as a single mass although 10% cases occur as multiple. CE clinically appears as a pedunculated protuberant mass, which may interfere with respiration or feeding. In cases with large lesions mechanical oral and nasal obstruction can impair fetal deglutition and neonatal respiratory efforts resulting in polyhydramnios prenatally or respiratory impairment postnatally. The exact histiogenesis is still uncertain. The recommended treatment is prompt surgical resection. Recurrences of the tumor and damage to future dentition have not been reported. Spontaneous regression of congenital epulis has been reported in a few cases. However, surgical excision is generally indicated due to interference with feeding or respiration. We report a female neonate with congenital multiple tumors in the anterior maxillary alveolar ridge and review the relevant literature. The tumors were resected by surgical excision. The intraoperative and postoperative course was uneventful. Follow-up for 6 months did not show recurrence.

摘要

先天性牙龈瘤(CE)是一种罕见的新生儿肿瘤,因其组织学特征也被称为颗粒细胞瘤或先天性牙龈颗粒细胞瘤。诺伊曼于1871年首次描述了CE。牙龈瘤仅见于新生儿,是一种与其他颗粒细胞瘤不同的实体。CE有女性偏好,男女比例为8:1。牙龈瘤最常位于上颌前牙槽嵴,通常表现为单个肿块,不过10%的病例为多发。CE临床上表现为带蒂的突出肿块,可能会干扰呼吸或进食。在病变较大的情况下,口腔和鼻腔的机械性阻塞会损害胎儿吞咽和新生儿呼吸功能,导致产前羊水过多或产后呼吸功能受损。确切的组织发生仍不确定。推荐的治疗方法是及时手术切除。尚未有肿瘤复发和对未来牙列造成损害的报道。少数病例报告了先天性牙龈瘤的自发消退。然而,由于干扰进食或呼吸,一般仍需手术切除。我们报告了一名在上颌前牙槽嵴有先天性多发肿瘤的女新生儿,并复习相关文献。肿瘤通过手术切除。术中及术后过程顺利。随访6个月未显示复发。

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