通过甲亚胺叶立德的一锅法双分子内1,3-偶极环加成反应合成含氟和不含氟的多环体系。
Synthesis of fluorous and nonfluorous polycyclic systems by one-pot, double intramolecular 1,3-dipolar cycloaddition of azomethine ylides.
作者信息
Zhang Wei, Lu Yimin, Geib Steven
机构信息
Fluorous Technologies, Inc., University of Pittsburgh Applied Research Center, 970 William Pitt Way, Pittsburgh, Pennsylvania 15238, USA.
出版信息
Org Lett. 2005 May 26;7(11):2269-72. doi: 10.1021/ol0507773.
PMID:15901186
Abstract
[reaction: see text]. Under microwave irradiation, a one-pot, double intramolecular [3 + 2]-cycloaddition reaction of azomethine ylides leads to formation of a novel hexacyclic ring system. The major diastereomer is isolated, and its stereochemistry is determined by X-ray crystal structure analysis.
摘要
[反应：见正文]。在微波辐射下，甲亚胺叶立德的一锅法双分子内[3 + 2]环加成反应导致形成一种新型的六元环体系。分离出主要的非对映异构体，并通过X射线晶体结构分析确定其立体化学。
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