四组分多米诺反应提供了一种易于获得多功能化三环[6.2.2.0(1,6)]十二烷衍生物的方法。
Four-component domino reaction providing an easy access to multifunctionalized tricyclo[6.2.2.0(1,6)]dodecane derivatives.
机构信息
School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, Jiangsu, People's Republic of China.
出版信息
J Org Chem. 2010 May 7;75(9):2962-5. doi: 10.1021/jo1002278.
Abstract
A novel four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and Cs(2)CO(3) in ethylene glycol under microwave heating. The reaction proceeds at fast rates and can be finished within 15-24 min, which makes workup convenient. Four stereogenic centers with one quaternary carbon-amino function have been controlled completely. The stereochemistry has been unequivocally determined by X-ray structural analysis. The resulting tricyclo[6.2.2.0(1,6)]dodecane derivatives are of importance for organic and medicinal research.
摘要
一种新的四组分多米诺反应已经被发现。该反应通过简单地将四个常见的反应物和 Cs(2)CO(3)在微波加热下混合在乙二醇中即可进行。反应速度快，可以在 15-24 分钟内完成，这使得后处理方便。四个立体中心和一个季碳-氨基官能团完全得到控制。立体化学通过 X 射线结构分析得到明确的确定。得到的三环[6.2.2.0(1,6)]十二烷衍生物对有机和药物研究具有重要意义。
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