杀伤性 B 淋巴细胞：证据与潜能
Killer B lymphocytes: the evidence and the potential.
机构信息
Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109-2200, USA.
出版信息
Inflamm Res. 2009 Jul;58(7):345-57. doi: 10.1007/s00011-009-0014-x. Epub 2009 Mar 5.
Abstract
Immune regulation plays a critical role in controlling potentially dangerous inflammation and maintaining health. The Fas ligand/Fas receptor axis has been studied extensively as a mechanism of killing T cells and other cells during infections, autoimmunity, and cancer. FasL expression has been primarily attributed to activated T cells and NK cells. Evidence has emerged that B lymphocytes can express FasL and other death-inducing ligands, and can mediate cell death under many circumstances. Among B cell subsets, the expression of both Fas ligand and IL-10 is highest on the CD5(+) B cell population, suggesting that CD5(+) B cells may have a specialized regulatory function. The relevance of killer B cells to normal immune regulation, disease pathogenesis, and inflammation is discussed.
摘要
免疫调节在控制潜在危险的炎症和维持健康方面起着关键作用。Fas 配体/Fas 受体轴已被广泛研究作为感染、自身免疫和癌症期间杀死 T 细胞和其他细胞的机制。FasL 的表达主要归因于活化的 T 细胞和 NK 细胞。有证据表明 B 淋巴细胞可以表达 FasL 和其他诱导细胞死亡的配体，并在许多情况下介导细胞死亡。在 B 细胞亚群中，CD5+B 细胞群上 Fas 配体和 IL-10 的表达最高，表明 CD5+B 细胞可能具有特殊的调节功能。讨论了杀伤 B 细胞与正常免疫调节、疾病发病机制和炎症的相关性。
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