Suppr超能文献

表达Fas配体的B-1a淋巴细胞在血吸虫感染过程中介导CD4(+) T细胞凋亡:由白细胞介素4(IL-4)和IL-10诱导

Fas ligand-expressing B-1a lymphocytes mediate CD4(+)-T-cell apoptosis during schistosomal infection: induction by interleukin 4 (IL-4) and IL-10.

作者信息

Lundy Steven K, Boros Dov L

机构信息

Department of Immunology and Microbiology, Wayne State University, School of Medicine, Detroit, Michigan 48201.

出版信息

Infect Immun. 2002 Feb;70(2):812-9. doi: 10.1128/IAI.70.2.812-819.2002.

Abstract

A previous study of the murine model of Schistosoma mansoni infection has implicated splenic CD19(+) B lymphocytes as Fas ligand (FasL)-bearing mediators of CD4(+) T-lymphocyte apoptosis. The present study shows that B-cell deficiency leads to decreased CD4(+) T-cell apoptosis during infection and compares FasL expression and killer function of B-1a- and CD5(-) B-lymphocyte subsets. B-1a cells from uninfected mice displayed constitutive expression of FasL compared with that of CD5(-) B cells. FasL expression was enhanced following worm egg deposition and antigenic stimulation on both subsets of B cells. Purified B-1a cells from uninfected mice were potent effectors of CD4(+) T-cell apoptosis, and the killing effect was enhanced during schistosome infection. FasL expression by splenic B cells required CD4(+)-T-cell help that was replaced by addition of culture supernatants from antigen-stimulated splenocytes of infected mice. The culture-supernatant-stimulated FasL expression was inhibited by anti-interleukin 10 (IL-10) and anti-IL-4 antibodies. Culture of purified B cells with recombinant IL-4 (rIL-4), rIL-10, and soluble egg antigens (SEA) led to increased expression of FasL on B-1a cells. These results suggest that FasL-expressing, splenic B-1a cells are important mediators of SEA-stimulated CD4(+)-T-cell apoptosis and that maximal FasL expression on B-1a cells is dependent on antigenic stimulation and the presence of IL-4 and IL-10.

摘要

先前一项关于曼氏血吸虫感染小鼠模型的研究表明,脾脏CD19(+) B淋巴细胞是携带Fas配体(FasL)的CD4(+) T淋巴细胞凋亡介质。本研究表明,B细胞缺陷会导致感染期间CD4(+) T细胞凋亡减少,并比较了B-1a和CD5(-) B淋巴细胞亚群的FasL表达及杀伤功能。与CD5(-) B细胞相比,未感染小鼠的B-1a细胞呈现FasL的组成性表达。在虫卵沉积和抗原刺激后,两个B细胞亚群的FasL表达均增强。未感染小鼠的纯化B-1a细胞是CD4(+) T细胞凋亡的有效效应细胞,且在血吸虫感染期间杀伤作用增强。脾脏B细胞的FasL表达需要CD4(+) T细胞的辅助,而添加感染小鼠抗原刺激脾细胞的培养上清液可替代这种辅助。抗白细胞介素10(IL-10)和抗IL-4抗体可抑制培养上清液刺激的FasL表达。用重组IL-4(rIL-4)、rIL-10和可溶性虫卵抗原(SEA)培养纯化的B细胞,可导致B-1a细胞上FasL表达增加。这些结果表明,表达FasL的脾脏B-1a细胞是SEA刺激的CD4(+) T细胞凋亡的重要介质,且B-1a细胞上FasL的最大表达依赖于抗原刺激以及IL-4和IL-10的存在。

相似文献

3
Reduced Fas ligand-expressing splenic CD5+ B lymphocytes in severe collagen-induced arthritis.
Arthritis Res Ther. 2009;11(4):R128. doi: 10.1186/ar2795. Epub 2009 Aug 25.
7
IL-10 deficit correlates with chronic, hypersplenomegaly syndrome in male CBA/J mice infected with Schistosoma mansoni.
Parasite Immunol. 1997 Aug;19(8):347-53. doi: 10.1046/j.1365-3024.1997.d01-224.x.
9
Schistosome egg antigens, including the glycoprotein IPSE/alpha-1, trigger the development of regulatory B cells.
PLoS Pathog. 2017 Jul 28;13(7):e1006539. doi: 10.1371/journal.ppat.1006539. eCollection 2017 Jul.

引用本文的文献

1
2
Frontiers and Controversies in De Novo Gastrointestinal Tumors After Organ Transplantation: Current Progress and Future Directions.
Ann Surg Oncol. 2025 May;32(5):3392-3405. doi: 10.1245/s10434-025-16975-w. Epub 2025 Mar 4.
3
excretory/secretory products: an untapped library of tolerogenic immunotherapeutics against food allergy.
Clin Transl Immunology. 2024 Aug 29;13(9):e70001. doi: 10.1002/cti2.70001. eCollection 2024 Sep.
4
Regulatory B Cells in Solid Organ Transplantation: From Immune Monitoring to Immunotherapy.
Transplantation. 2024 May 1;108(5):1080-1089. doi: 10.1097/TP.0000000000004798. Epub 2023 Oct 2.
5
Homeostatic role of B-1 cells in tissue immunity.
Front Immunol. 2023 Sep 8;14:1106294. doi: 10.3389/fimmu.2023.1106294. eCollection 2023.
6
Suppressive mechanisms of regulatory B cells in mice and humans.
Int Immunol. 2023 Feb 11;35(2):55-65. doi: 10.1093/intimm/dxac048.
7
Regulatory B Cell Therapy in Kidney Transplantation.
Front Pharmacol. 2021 Dec 7;12:791450. doi: 10.3389/fphar.2021.791450. eCollection 2021.
8
The Dynamics of B Cell Aging in Health and Disease.
Front Immunol. 2021 Oct 5;12:733566. doi: 10.3389/fimmu.2021.733566. eCollection 2021.
9
Regulatory B Cells: Role in Type 1 Diabetes.
Front Immunol. 2021 Sep 20;12:746187. doi: 10.3389/fimmu.2021.746187. eCollection 2021.
10
Immunosuppressive Mechanisms of Regulatory B Cells.
Front Immunol. 2021 Apr 29;12:611795. doi: 10.3389/fimmu.2021.611795. eCollection 2021.

本文引用的文献

1
B cell development pathways.
Annu Rev Immunol. 2001;19:595-621. doi: 10.1146/annurev.immunol.19.1.595.
2
B1 cells: similarities and differences with other B cell subsets.
Curr Opin Immunol. 2001 Apr;13(2):195-201. doi: 10.1016/s0952-7915(00)00204-1.
4
CD95's deadly mission in the immune system.
Nature. 2000 Oct 12;407(6805):789-95. doi: 10.1038/35037728.
8
T helper cell populations, cytokine dynamics, and pathology of the schistosome egg granuloma.
Microbes Infect. 1999 Jun;1(7):511-6. doi: 10.1016/s1286-4579(99)80090-2.
9
X-linked immunodeficiency affects the outcome of Schistosoma mansoni infection in the murine model.
Parasite Immunol. 1999 Feb;21(2):89-101. doi: 10.1046/j.1365-3024.1999.00205.x.

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验