裸花紫珠对紫外线B辐射诱导的无毛小鼠表皮致癌相关生物标志物的光保护作用。
Photoprotective effect of Pothomorphe umbellata on UVB radiation-induced biomarkers involved in carcinogenesis of hairless mouse epidermis.
作者信息
da Silva Vanessa Vitoriano, Ropke Cristina Dislich, Miranda Denise Varella, de Almeida Rebeca Leite, Sawada Tânia Cristina Higashi, Rivelli Diogo Pineda, Barros Silvia Berlanga de Moraes
机构信息
Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas da Universidade de São Paulo, São Paulo, Brasil.
出版信息
Cutan Ocul Toxicol. 2009;28(2):54-60. doi: 10.1080/15569520902784014.
In this study we assessed the protective effect of topical application of Pothomorphe umbellata extract on ultraviolet B (UVB)-induced skin lesion parameters in hairless mouse epidermis. A single dose of UVB irradiation (0.23 kJ/m2) resulted in a significant decrease in thymine dimer-positive cells and apoptotic sunburn cells, with an increase in p53 and proliferating cell nuclear antigen-positive cells in the epidermis. After 5 weeks (total dose 13.17 kJ/m2) and 15 weeks (total dose 55.51 kJ/m2) of irradiation, P. umbellata treatment inhibited the hyperplasic response and induced an increase in p53-positive cells. These findings suggest that P. umbellata extract affords protection against UVB-induced skin lesions.
在本研究中，我们评估了局部应用伞花胡椒提取物对无毛小鼠表皮中紫外线B（UVB）诱导的皮肤损伤参数的保护作用。单次剂量的UVB照射（0.23 kJ/m2）导致胸腺嘧啶二聚体阳性细胞和凋亡性晒伤细胞显著减少，同时表皮中p53和增殖细胞核抗原阳性细胞增加。照射5周（总剂量13.17 kJ/m2）和15周（总剂量55.51 kJ/m2）后，伞花胡椒处理抑制了增生反应，并诱导p53阳性细胞增加。这些发现表明，伞花胡椒提取物对UVB诱导的皮肤损伤具有保护作用。
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