Department of Pharmaceutical Technology, Jadavpur University Kolkata, India.
Front Pharmacol. 2012 Jan 9;2:94. doi: 10.3389/fphar.2011.00094. eCollection 2011.
Treatment of cancer often requires exposure to radiation, which has several limitations involving non-specific toxicity toward normal cells, reducing the efficacy of treatment. Efforts are going on to find chemical compounds which would effectively offer protection to the normal tissues after radiation exposure during radiotherapy of cancer. In this regard, plant-derived compounds might serve as "leads" to design ideal radioprotectors/radiosensitizers. This article reviews some of the recent findings on prospective medicinal plants, phytochemicals, and their analogs, based on both in vitro and in vivo tumor models especially focused with relevance to cancer radiotherapy. Also, pertinent discussion has been presented on the molecular mechanism of apoptotic death in relation to the oxidative stress in cancer cells induced by some of these plant samples and their active constituents.
癌症的治疗通常需要接受辐射，而辐射具有一些局限性，涉及对正常细胞的非特异性毒性，从而降低了治疗的效果。目前正在努力寻找化学化合物，以便在癌症放射治疗中辐射暴露后，为正常组织提供有效的保护。在这方面，植物衍生的化合物可能成为设计理想的放射保护剂/增敏剂的“先导”。本文综述了一些基于体外和体内肿瘤模型的有前途的药用植物、植物化学物质及其类似物的最新发现，特别是与癌症放射治疗有关的内容。此外，还就这些植物样本及其活性成分诱导癌细胞发生氧化应激与细胞凋亡死亡的分子机制进行了相关讨论。
