Department of Pharmacology, Anaesthesiology and Therapeutics, Faculty of Dentistry, University of Campinas, Avenida Limeira 901, 13414-903 Piracicaba, SP, Brazil ; Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paulínia, SP, Brazil.
Chemical, Biological and Agricultural Pluridisciplinary Research Center (CPQBA), University of Campinas, Rua Alexandre Cazelatto 999, Vila Betel, 13148-218 Paulínia, SP, Brazil ; Department of Organic Chemistry, Institute of Chemistry, University of Campinas, Rua Josué de Castro s/n, Cidade Universitária Zeferino Vaz, Barão Geraldo, 13081-970 Campinas, SP, Brazil.
Evid Based Complement Alternat Med. 2015;2015:948737. doi: 10.1155/2015/948737. Epub 2015 Feb 3.
Despite the advances in anticancer drug discovery field, the worldwide cancer incidence is remarkable, highlighting the need for new therapies focusing on both cancer cell and its microenvironment. The tumor microenvironment offers multiple targets for cancer therapy, including inflammation. Nowadays, almost 75% of the anticancer agents used in chemotherapy are derived from natural products, and plants are an important source of new promising therapies. Continuing our research on Piper umbellatum species, here we describe the anticancer (in vitro antiproliferative activity and in vivo Ehrlich solid tumor model) and anti-inflammatory (carrageenan-induced paw edema and peritonitis models) activities of a standardized dichloromethane extract (SDE) from P. umbellatum leaves, containing 23.9% of 4-nerolidylcatechol. SDE showed in vitro and in vivo antiproliferative activity, reducing Ehrlich solid tumor growth by 38.7 and 52.2% when doses of 200 and 400 mg/kg, respectively, were administered daily by oral route. Daily treatments did not produce signals of toxicity. SDE also reduced paw edema and leukocyte migration on carrageenan-induced inflammation models, suggesting that the anticancer activity of SDE from Piper umbellatum leaves could involve antiproliferative and anti-inflammatory effects. These findings highlight P. umbellatum as a source of compounds against cancer and inflammation.
尽管在抗癌药物发现领域取得了进展，但全球癌症发病率仍然显著，这凸显了需要新的治疗方法，既要针对癌细胞，又要针对其微环境。肿瘤微环境为癌症治疗提供了多个靶点，包括炎症。如今，在化疗中使用的近 75%的抗癌药物来自天然产物，而植物是新的有前途的治疗方法的重要来源。在继续对胡椒属植物进行研究的基础上，我们在这里描述了从胡椒属植物叶子中提取的一种标准化二氯甲烷提取物（SDE）的抗癌（体外增殖活性和体内艾氏腹水瘤模型）和抗炎（角叉菜胶诱导的爪水肿和腹膜炎模型）活性，该提取物含有 23.9%的 4-香叶基儿茶酚。SDE 表现出体外和体内的增殖活性，当以 200 和 400mg/kg 的剂量通过口服途径每天给药时，分别使艾氏腹水瘤的生长减少了 38.7%和 52.2%。每日治疗不会产生毒性信号。SDE 还减轻了角叉菜胶诱导的炎症模型中的爪水肿和白细胞迁移，表明来自胡椒属植物叶子的 SDE 的抗癌活性可能涉及抗增殖和抗炎作用。这些发现强调了胡椒属植物作为抗癌和抗炎化合物的来源。
