Hincapié-Zapata M E, Suárez-Escudero J C, Pineda-Tamayo R, Anaya J M
Centro de Estudio de Enfermedades Autoinmunes, Universidad del Rosario, Bogota DC, Colombia.
Rev Neurol. 2009;48(5):225-30.
Diseases that involve the nervous system and the musculoskeletal system are particularly likely to produce different limitations and deficits, and to affect the individual conception of quality of life.
To determine the impact on quality of life generated by chronic autoimmune diseases like multiple sclerosis (MS), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), ankylosing spondylitis (AS) and chronic musculotendinous diseases like osteoarthritis (OA) and fibromyalgia (FM), using the Short Form 36-item (SF-36) health questionnaire.
A descriptive cross-sectional study was conducted between January 2004 and June 2006 and included 509 individuals, of whom 56 had MS, 36 SS, 24 AS, 200 RA, 65 SLE, 54 OA and 74 FM. Guided interviews were conducted to evaluate each sphere of the SF-36 health questionnaire. The statistical analysis was performed using the general lineal model, with means differences according to each diagnosis.
Compared to patients with RA, those with MS showed significant differences in the physical functioning and social functioning dimensions. The lowest score was recorded in those with FM, except in physical functioning, where MS had the lowest mean. No differences were found in the mean scores on general conception of the state of health in each condition analysed.
Different neurological functions deteriorate progressively in MS, which has repercussions on the musculoskeletal system; this leads to a poorer quality of life, mainly in the physical and social functions. The disability generated is not only defined by deficit but also by the degrees of functional limitation within the context of personal health. Quality of life thus becomes a global biopsychosocial phenomenon.
涉及神经系统和肌肉骨骼系统的疾病特别容易产生不同的限制和缺陷，并影响个人对生活质量的认知。
使用36项简短健康调查问卷（SF-36），确定多发性硬化症（MS）、类风湿性关节炎（RA）、系统性红斑狼疮（SLE）、干燥综合征（SS）、强直性脊柱炎（AS）等慢性自身免疫性疾病以及骨关节炎（OA）和纤维肌痛（FM）等慢性肌肉骨骼疾病对生活质量产生的影响。
2004年1月至2006年6月进行了一项描述性横断面研究，纳入509名个体，其中56人患有MS，36人患有SS，24人患有AS，200人患有RA，65人患有SLE，54人患有OA，74人患有FM。进行了指导性访谈以评估SF-36健康调查问卷的各个方面。使用一般线性模型进行统计分析，并根据每种诊断得出均值差异。
与RA患者相比，MS患者在身体功能和社会功能维度上存在显著差异。FM患者得分最低，但在身体功能方面，MS患者的平均分最低。在所分析的每种疾病的健康总体认知平均得分方面未发现差异。
MS患者的不同神经功能逐渐恶化，这对肌肉骨骼系统产生影响；这导致生活质量较差，主要体现在身体和社会功能方面。所产生的残疾不仅由缺陷定义，还由个人健康背景下的功能受限程度定义。因此，生活质量成为一种整体的生物心理社会现象。
