Visone Rosa, Croce Carlo M
Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, 460 West, 12th Ave., Columbus, OH 43210, USA.
Am J Pathol. 2009 Apr;174(4):1131-8. doi: 10.2353/ajpath.2009.080794. Epub 2009 Mar 5.
Cancer is the result of a complex multistep process that involves the accumulation of sequential alterations of several genes, including those encoding microRNAs (miRNAs). miRNAs are a class of 17- to 27-nucleotide single-stranded RNA molecules that regulate gene expression posttranscriptionally. A large body of evidence implicates aberrant miRNA expression patterns in most, if not all, human malignancies. This article reviews our current knowledge about miRNAs, focusing on their involvement in cancer and their potential as diagnostic, prognostic, and therapeutic tools.
癌症是一个复杂的多步骤过程的结果,该过程涉及多个基因的序列改变的积累,包括那些编码微小RNA(miRNA)的基因。miRNA是一类17至27个核苷酸的单链RNA分子,它们在转录后调节基因表达。大量证据表明,在大多数(如果不是全部)人类恶性肿瘤中,miRNA表达模式异常。本文综述了我们目前对miRNA的认识,重点关注它们在癌症中的作用以及作为诊断、预后和治疗工具的潜力。