糖尿病与阿尔茨海默病之间的共同特征。
Common features between diabetes mellitus and Alzheimer's disease.
作者信息
Götz J, Ittner L M, Lim Y-A
机构信息
Brain and Mind Research Institute, University of Sydney, Camperdown, NSW, Australia.
出版信息
Cell Mol Life Sci. 2009 Apr;66(8):1321-5. doi: 10.1007/s00018-009-9070-1.
Epidemiological studies establish a link between Type 2 diabetes (T2DM) and Alzheimer's disease (AD), both leading causes of morbidity and mortality in the elderly. These diseases also share clinical and biochemical features suggesting common pathogenic mechanisms. Specifically, both are amyloidoses as they are characterized by fibrillar protein aggregates - amylin in T2DM pancreatic islets, and beta-amyloid (Abeta) and neurofibrillary tangles (NFTs) in AD brain. Amylin aggregation is associated with pancreatic beta-cell loss, and Abeta and NFT formation with neuronal cell loss. We discuss the possibility that amylin and Abeta exert their toxicity by similar mechanisms, with components of the pathocascades shared, and that therapies based on amyloidogenic properties are beneficial for both T2DM and AD.
流行病学研究证实了2型糖尿病（T2DM）与阿尔茨海默病（AD）之间的联系，这两种疾病都是老年人发病和死亡的主要原因。这些疾病还具有共同的临床和生化特征，提示存在共同的致病机制。具体而言，两者均为淀粉样变性疾病，其特征是出现纤维状蛋白质聚集体——T2DM患者胰岛中的胰岛淀粉样多肽，以及AD患者大脑中的β-淀粉样蛋白（Aβ）和神经原纤维缠结（NFTs）。胰岛淀粉样多肽聚集与胰腺β细胞丢失有关，而Aβ和NFT形成与神经元细胞丢失有关。我们探讨了胰岛淀粉样多肽和Aβ通过相似机制发挥毒性作用、病理级联反应的组成部分相同，以及基于淀粉样变性特性的疗法对T2DM和AD均有益的可能性。
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