Oka Kuniyuki, Nagayama Reizo, Mori Naoyoshi
Pathology, Mito Saiseikai General Hospital, Mito, Ibaraki, Japan.
Pathol Res Pract. 2009;205(10):730-4. doi: 10.1016/j.prp.2009.01.014. Epub 2009 Mar 9.
We describe a patient who was diagnosed as having classic Hodgkin's lymphoma at 29 years of age, and aggressive natural killer-cell leukemia at 48 years. He died 42 days later. Hodgkin and Reed-Sternberg cells in the lymph node expressed CD30, CD15, T-cell intracellular antigen-1 (TIA-1), perforin, granzyme B, and Epstein-Barr virus-encoded RNA (EBER). Natural killer-cell leukemia cells in the bone marrow expressed cytoplasmic CD3epsilon, TIA-1, perforin, granzyme B, and EBER, and some neoplastic cells expressed CD56 (123C3). Fluorescence-activated cell sorter (FACS) analysis showed that neoplastic cells expressed CD56. Neither a rearrangement band of the T-cell receptor gene nor that of the immunoglobulin heavy chain gene was detected. Chromosomal abnormalities were noted.
我们描述了一名患者，他29岁时被诊断为经典型霍奇金淋巴瘤，48岁时患侵袭性自然杀伤细胞白血病。42天后他去世。淋巴结中的霍奇金和里德-斯腾伯格细胞表达CD30、CD15、T细胞细胞内抗原-1（TIA-1）、穿孔素、颗粒酶B和爱泼斯坦-巴尔病毒编码RNA（EBER）。骨髓中的自然杀伤细胞白血病细胞表达细胞质CD3ε、TIA-1、穿孔素、颗粒酶B和EBER，一些肿瘤细胞表达CD56（123C3）。荧光激活细胞分选仪（FACS）分析显示肿瘤细胞表达CD56。未检测到T细胞受体基因或免疫球蛋白重链基因的重排带。发现了染色体异常。
