Wanitphakdeedecha Rungsima, Tanzi Elizabeth L, Alster Tina S
Department of Dermatology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
J Drugs Dermatol. 2009 Mar;8(3):239-41.
A wide variety of laser and light-based therapies have been utilized for acne vulgaris; however, current techniques have been limited by photosensitivity issues or inconsistent results.
To determine the clinical efficacy and side-effect profile of photopneumatic therapy for the treatment of facial acne vulgaris.
Twenty adults with mild to severe facial acne vulgaris received 4 successive treatments at 2-week intervals with a combined photopneumatic device (intense pulsed light [IPL]: fluences = 3.6-4.2 J/cm2; negative pressure = 3 psi). Clinical improvement was evaluated on a quartile grading scale using comparative digital photographs at baseline, and 1 month and 3 months after the final treatment. Acne lesion counts were obtained at baseline, prior to each treatment session, and at the end of the study.
Modest reduction in acne lesion counts and global clinical improvement was seen in the majority of patients. Patients with severe acne experienced the most clinical improvement. Side effects were mild and limited to transient erythema and rare purpura. Most patients experienced acne worsening early in the treatment course.
Photopneumatic therapy is a safe and effective treatment for acne vulgaris. Patients with more severe acne respond best to treatment.
多种基于激光和光的疗法已被用于寻常痤疮的治疗;然而,目前的技术受到光敏性问题或结果不一致的限制。
确定光气动疗法治疗面部寻常痤疮的临床疗效和副作用情况。
20名患有轻至重度面部寻常痤疮的成年人,使用联合光气动设备(强脉冲光[IPL]:能量密度=3.6 - 4.2 J/cm²;负压=3 psi),每隔2周连续接受4次治疗。在基线、最后一次治疗后1个月和3个月时,使用对比数码照片,根据四分位数分级量表评估临床改善情况。在基线、每次治疗前和研究结束时记录痤疮皮损数量。
大多数患者的痤疮皮损数量有适度减少,整体临床状况有所改善。重度痤疮患者的临床改善最为明显。副作用轻微,仅限于短暂的红斑和罕见的紫癜。大多数患者在治疗过程早期出现痤疮加重的情况。
光气动疗法是治疗寻常痤疮的一种安全有效的方法。痤疮较严重的患者对治疗反应最佳。