Spectrum Health Genetic Services, Grand Rapids, MI 49503, USA.
Pediatr Clin North Am. 2010 Jun;57(3):719-27. doi: 10.1016/j.pcl.2010.02.006.
"Gene doping" is the term used to describe the potential abuse of gene therapy as a performance-enhancing agent. Gene doping would apply the techniques used in gene therapy to provide altered expression of genes that would promote physical superiority. For example, insulin-like growth factor 1 (IGF-1) is a primary target for growth hormone; overexpression of IGF-1 can lead to increased muscle mass and power. Although gene doping is still largely theoretical, its implications for sports, health, ethics, and medical genetics are significant.
“基因兴奋剂”是指将基因治疗技术滥用于提高运动成绩的行为。基因兴奋剂将采用基因治疗技术，改变促进身体优势的基因表达。例如，胰岛素样生长因子 1（IGF-1）是生长激素的主要靶点；IGF-1 的过表达可导致肌肉质量和力量增加。尽管基因兴奋剂在很大程度上仍处于理论阶段，但它对运动、健康、伦理和医学遗传学的影响意义重大。
