中国上海肺炎支原体分离株的抗菌药敏性及大环内酯类耐药菌株的分子分析
Antimicrobial susceptibility of Mycoplasma pneumoniae isolates and molecular analysis of macrolide-resistant strains from Shanghai, China.
作者信息
Liu Yang, Ye Xinyu, Zhang Hong, Xu Xiaogang, Li Wanhua, Zhu Demei, Wang Minggui
机构信息
Institute of Antibiotics, Huashan Hospital, Fudan University, 12 M. Wulumuqi Rd., Shanghai 200040, People's Republic of China.
出版信息
Antimicrob Agents Chemother. 2009 May;53(5):2160-2. doi: 10.1128/AAC.01684-08. Epub 2009 Mar 9.
Abstract
Fifty-three Mycoplasma pneumoniae strains were isolated from pediatric patients in Shanghai, China, from October 2005 to February 2008. Of 53 clinical isolates, 44 (83%) were resistant to erythromycin (MICs of >128 microg/ml for all 44 strains), azithromycin, and clarithromycin. All macrolide-resistant M. pneumoniae strains harbored an A-to-G transition mutation at position 2063 in 23S rRNA genes. Forty-five (85%) clinical isolates were classified into the P1 gene restriction fragment length polymorphism type I, and six (11%) were type II.
摘要
2005年10月至2008年2月期间，从中国上海的儿科患者中分离出53株肺炎支原体菌株。在这53株临床分离株中，44株（83%）对红霉素（所有44株的最低抑菌浓度均>128μg/ml）、阿奇霉素和克拉霉素耐药。所有对大环内酯类耐药的肺炎支原体菌株在23S rRNA基因的2063位均存在A到G的转换突变。45株（85%）临床分离株被分类为P1基因限制性片段长度多态性I型，6株（11%）为II型。
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