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中国肺炎支原体临床分离株大环内酯类耐药的分子机制

Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.

作者信息

Xin Deli, Mi Zuhuang, Han Xu, Qin Ling, Li Jing, Wei Tianli, Chen Xiaogeng, Ma Shaojie, Hou Ancun, Li Gui, Shi Dawei

机构信息

Pediatric Department of Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Road, XuanWu District, Beijing 100050, China.

出版信息

Antimicrob Agents Chemother. 2009 May;53(5):2158-9. doi: 10.1128/AAC.01563-08. Epub 2009 Mar 9.

DOI:10.1128/AAC.01563-08
PMID:19273685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2681523/
Abstract

Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.

摘要

从370名呼吸道感染儿童中分离出50株临床肺炎支原体菌株。4株对大环内酯类药物敏感，而其他46株（92%）对大环内酯类药物耐药。耐药的分子机制显示与23S rRNA第2063和2064位的点突变有关。

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本文引用的文献

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Detection of macrolide resistance in Mycoplasma pneumoniae by real-time PCR and high-resolution melt analysis.通过实时聚合酶链反应和高分辨率熔解分析检测肺炎支原体中的大环内酯类耐药性。
Antimicrob Agents Chemother. 2008 Oct;52(10):3542-9. doi: 10.1128/AAC.00582-08. Epub 2008 Jul 21.
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First report of macrolide-resistant strains and description of a novel nucleotide sequence variation in the P1 adhesin gene in Mycoplasma pneumoniae clinical strains isolated in France over 12 years.法国12年间分离的肺炎支原体临床菌株中耐大环内酯类菌株的首次报告及P1黏附素基因新核苷酸序列变异的描述
J Clin Microbiol. 2007 Nov;45(11):3534-9. doi: 10.1128/JCM.01345-07. Epub 2007 Sep 19.
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Emergence of macrolide-resistant Mycoplasma pneumoniae with a 23S rRNA gene mutation.具有23S rRNA基因突变的大环内酯类耐药肺炎支原体的出现。
Antimicrob Agents Chemother. 2005 Jun;49(6):2302-6. doi: 10.1128/AAC.49.6.2302-2306.2005.
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[Resistance of Mycoplasma pneumoniae to macrolides antibiotics].肺炎支原体对大环内酯类抗生素的耐药性
Zhonghua Er Ke Za Zhi. 2005 Mar;43(3):212.
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Characterization and molecular analysis of macrolide-resistant Mycoplasma pneumoniae clinical isolates obtained in Japan.对在日本获得的大环内酯类耐药肺炎支原体临床分离株的特性鉴定及分子分析
Antimicrob Agents Chemother. 2004 Dec;48(12):4624-30. doi: 10.1128/AAC.48.12.4624-4630.2004.
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