中国肺炎支原体临床分离株大环内酯类耐药的分子机制
Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.
作者信息
Xin Deli, Mi Zuhuang, Han Xu, Qin Ling, Li Jing, Wei Tianli, Chen Xiaogeng, Ma Shaojie, Hou Ancun, Li Gui, Shi Dawei
机构信息
Pediatric Department of Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Road, XuanWu District, Beijing 100050, China.
出版信息
Antimicrob Agents Chemother. 2009 May;53(5):2158-9. doi: 10.1128/AAC.01563-08. Epub 2009 Mar 9.
Abstract
Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.
摘要
从370名呼吸道感染儿童中分离出50株临床肺炎支原体菌株。4株对大环内酯类药物敏感，而其他46株（92%）对大环内酯类药物耐药。耐药的分子机制显示与23S rRNA第2063和2064位的点突变有关。
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