左氧氟沙星与利福平联合用药对兔实验性耐甲氧西林金黄色葡萄球菌所致人工膝关节感染的杀菌活性。
Bactericidal activity of the combination of levofloxacin with rifampin in experimental prosthetic knee infection in rabbits due to methicillin-susceptible Staphylococcus aureus.
作者信息
Muller-Serieys Claudette, Saleh Mghir Azzam, Massias Laurent, Fantin Bruno
机构信息
Laboratoire de Microbiologie, AP-HP, Hôpital Bichat, Paris, France.
出版信息
Antimicrob Agents Chemother. 2009 May;53(5):2145-8. doi: 10.1128/AAC.01163-08. Epub 2009 Mar 9.
Abstract
The combination of levofloxacin and rifampin has been recommended for the treatment of staphylococcal prosthetic infection. In a rabbit model of prosthetic knee infection due to a susceptible clinical strain of Staphylococcus aureus, the combination of levofloxacin and rifampin was bactericidal, significantly reduced bacterial titers in bone compared with levels for rifampin and controls (P < 0.05), sterilized 6 of 12 animals, and prevented the selection of resistant mutants that was observed with rifampin alone, validating clinical recommendations.
摘要
左氧氟沙星和利福平联合用药已被推荐用于治疗葡萄球菌人工关节感染。在由一株对临床敏感的金黄色葡萄球菌引起的人工膝关节感染兔模型中，左氧氟沙星和利福平联合用药具有杀菌作用，与利福平及对照组相比，可显著降低骨组织中的细菌滴度（P<0.05），使12只动物中的6只实现细菌清除，并防止了单独使用利福平时出现的耐药突变株的产生，证实了临床推荐的合理性。
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