埃博拉病毒和马尔堡病毒感染中的药物靶点。
Drug targets in infections with Ebola and Marburg viruses.
作者信息
Gene Olinger G, Julia Biggins E, Vanessa Melanson R, Victoria Wahl-Jensen, Thomas Geisbert W, Lisa Hensley E
机构信息
United States Army Medical Research Institute of Infectious Diseases, Division of Virology, Frederick, Maryland 21702-5011, USA.
出版信息
Infect Disord Drug Targets. 2009 Apr;9(2):191-200. doi: 10.2174/187152609787847730.
The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.
用于治疗埃博拉病毒和马尔堡病毒的抗病毒药物研发进展缓慢。迄今为止，除了支持性治疗外，尚无经批准的有效治疗方法、预防措施、疗法或疫苗可用于治疗或预防丝状病毒感染。在本综述中，我们研究了目前可用于治疗丝状病毒感染的现有治疗方法、可用于丝状病毒药物研发的潜在治疗靶点，以及针对丝状病毒的各种药物靶向技术。
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