代谢综合征老年患者三年来膳食维生素D摄入量与身体成分变化
Dietary vitamin D intake and changes in body composition over three years in older adults with metabolic syndrome.
作者信息
Vázquez-Lorente Héctor, Ni Jiaqi, Babio Nancy, García-Arellano Ana, Romaguera Dora, Martínez J Alfredo, Estruch Ramon, Sánchez Vicente Martín, Vidal Josep, Fitó Montserrat, Bes-Rastrollo Maira, Konieczna Jadwiga, Martinez-Urbistondo Diego, Casas Rosa, García-Fernández Marcos, Olbeyra Romina Paula, Chaplin Alice, Zulet M Angeles, Salas-Salvadó Jordi
机构信息
Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentació, Nutrició, Desenvolupament i Salut Mental ANUT-DSM, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.
Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Alimentació, Nutrició, Desenvolupament i Salut Mental ANUT-DSM, Reus, Spain; Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.
出版信息
J Nutr Health Aging. 2025 Mar;29(3):100467. doi: 10.1016/j.jnha.2024.100467. Epub 2025 Jan 8.
BACKGROUND
Adequate intake of vitamin D through diet may offer benefits in terms of body composition.
OBJECTIVES
We aimed to evaluate the longitudinal relationship between dietary vitamin D intake and changes in body composition in older adults over one and three years under the context of a weight loss and lifestyle behavioral intervention.
DESIGN
Longitudinal study.
SETTING
Multicenter.
PARTICIPANTS
This longitudinal study included 715 aged participants (mean age 65.3 ± 5.0 years, 38% women) with overweight/obesity and metabolic syndrome.
MEASUREMENTS
Multivariable-adjusted mixed-effects linear regression models were fitted to investigate the longitudinal associations between dietary vitamin D intake (exposure) and body composition (outcome) with available data at baseline, one, and three years of follow-up. Data on dietary vitamin D intake was assessed using a validated 143-item food frequency questionnaire. Body composition variables (total body weight (kg), total fat mass (%), total lean mass (%), muscle-to-fat mass ratio, visceral adipose tissue (kg), and android-to-gynoid fat ratio) were measured by dual-energy X-ray absorptiometry.
RESULTS
Higher dietary vitamin D intake (for each μg/day) was associated with higher total lean mass (β: 0.10 %; 95% CI: 0.02 to 0.18; P: 0.017) and muscle-to-fat mass ratio (β: 1.00 × 10; 95% CI: 0.22 × 10 to 1.78 × 10; P: 0.011), and lower total body weight (β: -0.20 kg; 95% CI: -0.34 to -0.05; P: 0.007), total fat mass (β: -0.11 %; 95% CI: -0.19 to -0.02; P: 0.015), and visceral adipose tissue (β: -1.74 × 10 kg; 95% CI: -3.47 × 10 to -0.01 × 10; P: 0.048) at one year of follow-up in the group following the intervention in the multivariable-adjusted model.
CONCLUSION
Dietary vitamin D intake was associated with better body composition changes in the context of a weight loss and lifestyle intervention which led to notable changes in body composition at short term.
背景
通过饮食摄入充足的维生素D可能对身体成分有益。
目的
我们旨在评估在减肥和生活方式行为干预的背景下，老年人饮食中维生素D摄入量与1年和3年期间身体成分变化之间的纵向关系。
设计
纵向研究。
地点
多中心。
参与者
这项纵向研究纳入了715名年龄较大的参与者（平均年龄65.3±5.0岁，38%为女性），他们患有超重/肥胖和代谢综合征。
测量
采用多变量调整的混合效应线性回归模型，利用基线、1年和3年随访时的可用数据，研究饮食中维生素D摄入量（暴露因素）与身体成分（结果）之间的纵向关联。饮食中维生素D摄入量的数据通过一份经验证的包含143个条目的食物频率问卷进行评估。身体成分变量（总体重（kg）、总脂肪量（%）、总瘦体量（%）、肌肉与脂肪量之比、内脏脂肪组织（kg）以及腹部与臀部脂肪比例）通过双能X线吸收法测量。
结果
在多变量调整模型中，干预组随访1年时，较高的饮食维生素D摄入量（每微克/天）与较高的总瘦体量（β：0.10%；95%置信区间：0.02至0.18；P：0.017）和肌肉与脂肪量之比（β：1.00×10；95%置信区间：0.22×10至1.78×10；P：0.011）相关，与较低的总体重（β：-0.20 kg；95%置信区间：-0.34至-0.05；P：0.007）、总脂肪量（β：-0.11%；95%置信区间：-0.19至-0.02；P：0.015）和内脏脂肪组织（β：-1.74×10 kg；95%置信区间：-3.47×10至-0.01×10；P：0.048）相关。
结论
在减肥和生活方式干预的背景下，饮食中维生素D摄入量与更好的身体成分变化相关，这种干预在短期内导致了身体成分的显著变化。
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