Lattanzi Alessandra
Dipartimento di Chimica, Università di Salerno, Via Ponte don Melillo, 84084, Fisciano, Italy.
Chem Commun (Camb). 2009 Mar 28(12):1452-63. doi: 10.1039/b900098d. Epub 2009 Feb 20.
Readily accessible alpha,alpha-diarylprolinols have been recently exploited as useful organocatalysts in different asymmetric reactions. It has been proposed that they operate either via bifunctional activation of the reactive partners through non-covalent interactions or via formation of covalent enamine and iminium intermediates. This feature article describes the employment of alpha,alpha-diarylprolinols as catalysts in the epoxidation of alpha,beta-enones, aldol reaction, cycloaddition, and carbon-carbon and carbon-heteroatom bond forming reactions.
易于获得的α,α-二芳基脯氨醇最近已被用作不同不对称反应中有用的有机催化剂。有人提出，它们要么通过非共价相互作用对反应伙伴进行双功能活化，要么通过形成共价烯胺和亚胺鎓中间体来发挥作用。这篇专题文章描述了α,α-二芳基脯氨醇作为催化剂在α,β-烯酮的环氧化、羟醛反应、环加成以及碳-碳和碳-杂原子键形成反应中的应用。
