List Benjamin
Max-Planck-Institut für Kohlenforschung, 45470, Mülheim an der Ruhr, Germany.
Chem Commun (Camb). 2006 Feb 28(8):819-24. doi: 10.1039/b514296m. Epub 2006 Jan 20.
During the last six years the asymmetric catalysis of carbonyl transformations via iminium ion and enamine intermediates using chiral amines as organocatalysts has grown most remarkably. In this personal account an overview of this area is given. The field can be divided into two sub areas: (a) Iminium catalysis, which is typically used for cycloadditions and conjugate additions to enals and enones and (b) Enamine catalysis, which is commonly used in electrophilic alpha-substitution reactions of ketones and aldehydes. A common origin of the two catalysis principles is proposed and their recent merger in tandem sequences is discussed.
在过去六年中，使用手性胺作为有机催化剂通过亚胺离子和烯胺中间体对羰基转化进行的不对称催化发展最为显著。在这篇个人综述中，对该领域进行了概述。该领域可分为两个子领域：（a）亚胺催化，通常用于对烯醛和烯酮的环加成反应以及共轭加成反应；（b）烯胺催化，常用于酮和醛的亲电α-取代反应。提出了这两种催化原理的共同起源，并讨论了它们最近在串联序列中的合并情况。
