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(2R,3S,4R)-3,4-异亚丙基二氧基-2-(苯磺酰甲基)吡咯烷-1-醇

(2R,3S,4R)-3,4-Isopropyl-idenedi-oxy-2-(phenyl-sulfonyl-meth-yl)pyrrolidin-1-ol.

作者信息

Flores Mari Fe, Garcia Pilar, M Garrido Narciso, Sanz Francisca, Diez David

出版信息

Acta Crystallogr Sect E Struct Rep Online. 2012 Aug 1;68(Pt 8):o2560. doi: 10.1107/S1600536812033028. Epub 2012 Jul 28.

DOI:10.1107/S1600536812033028
PMID:22904989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3415002/
Abstract

The title compound, C(14)H(19)NO(5)S, was prepared by nucleophilic addition of the lithium derivative of methyl-phenyl-sulfone to (3S,4R)-3,4-isopropyl-idene-dioxy-pyrroline 1-oxide. There are four mol-ecules in the asymmetric unit. The crystal structure determination confirms the configuration of the chiral centres as 2R,3S,4R. In the crystal, pairs of O-H⋯N hydrogen bonds link the mol-ecules into dimers.

摘要

标题化合物C(14)H(19)NO(5)S是通过甲基苯基砜的锂衍生物与(3S,4R)-3,4-异丙基亚甲二氧基吡咯啉1-氧化物进行亲核加成反应制备而成。不对称单元中有四个分子。晶体结构测定确定了手性中心的构型为2R、3S、4R。在晶体中，O-H⋯N氢键对将分子连接成二聚体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/2d86b0d39986/e-68-o2560-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/39ede24e524e/e-68-o2560-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/54e2dac993f9/e-68-o2560-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/f2492f8e21c8/e-68-o2560-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/2d86b0d39986/e-68-o2560-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/39ede24e524e/e-68-o2560-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/54e2dac993f9/e-68-o2560-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/f2492f8e21c8/e-68-o2560-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf2b/3415002/2d86b0d39986/e-68-o2560-fig4.jpg

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本文引用的文献

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Synthesis of a new chiral pyrrolidine.新型手性吡咯烷的合成。
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