Burnier Laurent, Fontana Pierre, Kwak Brenda R, Angelillo-Scherrer Anne
Service and Central Laboratory of Hematology, Centre Hospitalier Universitaire Vaudois, Rue du Bugnon 46, CH-1011 Lausanne, Switzerland.
Thromb Haemost. 2009 Mar;101(3):439-51.
Considerable interest for cell-derived microparticles has emerged, pointing out their essential role in haemostatic response and their potential as disease markers, but also their implication in a wide range of physiological and pathological processes. They derive from different cell types including platelets - the main source of microparticles - but also from red blood cells, leukocytes and endothelial cells, and they circulate in blood. Despite difficulties encountered in analyzing them and disparities of results obtained with a wide range of methods, microparticle generation processes are now better understood. However, a generally admitted definition of microparticles is currently lacking. For all these reasons we decided to review the literature regarding microparticles in their widest definition, including ectosomes and exosomes, and to focus mainly on their role in haemostasis and vascular medicine.
细胞衍生的微粒已引发了广泛关注，这不仅表明它们在止血反应中具有重要作用以及作为疾病标志物的潜力，还显示出它们参与了广泛的生理和病理过程。微粒来源于不同的细胞类型，包括血小板（微粒的主要来源），也来源于红细胞、白细胞和内皮细胞，并且在血液中循环。尽管在分析微粒时遇到困难，且使用多种方法获得的结果存在差异，但目前对微粒生成过程的理解更为深入。然而，目前仍缺乏一个被普遍认可的微粒定义。基于所有这些原因，我们决定回顾关于最广义微粒（包括胞外体和外泌体）的文献，并主要关注它们在止血和血管医学中的作用。
