INSERM UMR-970, Paris Cardiovascular Research Center, 56 rue Leblanc, 75373 Paris Cedex 15, France.
Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):27-33. doi: 10.1161/ATVBAHA.110.218123.
Endothelial microparticles (EMP) are complex vesicular structures shed from activated or apoptotic endothelial cells. They play a remarkable role in coagulation, inflammation, endothelial function, and angiogenesis and thus disturb the vascular homeostasis, contributing to the progression of vascular diseases. As a cause or a consequence, elevated levels of EMP were found in plasma from patients with vascular diseases, where they serve as a surrogate marker of endothelial function. More recent data challenged the presumed deleterious role of EMP because they could promote cell survival, exert antiinflammatory effects, counteract coagulation processes, or induce endothelial regeneration. This review focuses on the ambivalent role of EMP in vascular homeostasis.
内皮细胞微粒（EMP）是从激活或凋亡的内皮细胞中脱落的复杂囊泡结构。它们在凝血、炎症、内皮功能和血管生成中发挥着重要作用，从而扰乱血管内稳态，促进血管疾病的进展。作为原因或结果，在血管疾病患者的血浆中发现 EMP 水平升高，它们可作为内皮功能的替代标志物。最近的数据对 EMP 假定的有害作用提出了质疑，因为它们可以促进细胞存活、发挥抗炎作用、抵消凝血过程或诱导内皮细胞再生。本文重点介绍 EMP 在血管内稳态中的双重作用。
