Igawa M
Hinyokika Kiyo. 1986 Nov;32(11):1649-62.
Eighty-nine patients with bladder cancer underwent multiple mucosal biopsies of the bladder mucosa 129 times between April 1980 and June 1983. In total there were 126 tumor specimens and 723 mucosal biopsies. Blood group antigens (BGA) were detected by means of the specific red cell adherence (SRCA) test in blood group A, AB, and B patients and direct immunoperoxidase method in blood group O patients. Histological abnormalities in this paper indicate transitional cell carcinoma, microinvasion of carcinoma in situ, carcinoma in situ, dysplasia and hyperplasia. The Kaplan-Meier's method was used for the estimation of recurrence-free rate and logrank test for testing the significance of difference in recurrence-free rate. The BGA-positive rate in mucosal biopsies was 17% for microinvasion of carcinoma in situ, 29% for carcinoma in situ, 47% for transitional cell carcinoma, 35% for dysplasia, 71% for hyperplasia, 100% for squamous metaplasia, 87% for proliferative cystitis and 77% for normal epithelium. Of histological findings, microinvasion of carcinoma in situ, carcinoma in situ, transitional cell carcinoma and dysplasia showed a significantly lower BGA-positive rate than proliferative cystitis and normal epithelium (P less than 0.001). The BGA-positive rate of main tumor was 61% in G1 tumors, 23% in G2 tumors and 21% in G3 tumors. The BGA-positive rate was shown to be decreasing with the increase in the histological grade of main tumor, and this reciprocal relationship was statistically significant (P less than 0.005). No statistical correlation between BGA in tumors and histological stage was found. The frequency of histological abnormalities in mucosal biopsy was 5.2% in patients with BGA-positive tumors, 21.2% in those with BGA-negative tumors, the difference being statistically significant (P less than 0.001). The 5-year recurrence-free rate after transurethral resection (TUR) was 57.3% in patients with BGA-positive tumors, 18.2% in those with BGA-negative tumors, the difference between the 2 groups being significant (P less than 0.001).
1980年4月至1983年6月期间，89例膀胱癌患者接受了129次膀胱黏膜多处活检。总共获得126份肿瘤标本和723份黏膜活检样本。对A、AB和B血型患者采用特异性红细胞黏附（SRCA）试验检测血型抗原（BGA），对O血型患者采用直接免疫过氧化物酶法检测。本文中的组织学异常包括移行细胞癌、原位癌微浸润、原位癌、发育异常和增生。采用Kaplan-Meier法估计无复发生存率，并采用对数秩检验来检验无复发生存率差异的显著性。黏膜活检中，原位癌微浸润的BGA阳性率为17%，原位癌为29%，移行细胞癌为47%，发育异常为35%，增生为71%，鳞状化生为100%，增殖性膀胱炎为87%，正常上皮为77%。在组织学结果中，原位癌微浸润、原位癌、移行细胞癌和发育异常的BGA阳性率显著低于增殖性膀胱炎和正常上皮（P＜0.001）。G1级肿瘤主瘤的BGA阳性率为61%，G2级肿瘤为23%，G3级肿瘤为21%。结果显示，BGA阳性率随主瘤组织学分级的增加而降低，这种反比关系具有统计学意义（P＜0.005）。未发现肿瘤中的BGA与组织学分期之间存在统计学相关性。BGA阳性肿瘤患者黏膜活检中组织学异常的发生率为5.2%，BGA阴性肿瘤患者为21.2%，差异具有统计学意义（P＜0.001）。经尿道切除术（TUR）后，BGA阳性肿瘤患者的5年无复发生存率为57.
