20-羟基蜕皮酮和保幼激素对果蝇雌性个体中章鱼胺代谢的影响。

Effects of 20-hydroxyecdysone and juvenile hormone on octopamine metabolism in females of Drosophila.

作者信息

Bogomolova E V, Adonyeva N V, Gruntenko N E, Rauschenbach I Yu

机构信息

Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia.

出版信息

Arch Insect Biochem Physiol. 2009 Apr;70(4):244-53. doi: 10.1002/arch.20298.

DOI:10.1002/arch.20298

PMID:19278013

Abstract

The effect of exogenous 20-hydroxyecdysone (20E) and juvenile hormone (JH) on the activities of the tyrosine decarboxylase (TDC), the first enzyme in octopamine (OA) synthesis, has been studied in young females of wild type D. virilis and D. melanogaster under normal and heat stress (38 degrees C) conditions. Flies fed 20E expressed increased TDC activity in both species. JH application decreased TDC activity in both species. A rise in JH and 20E levels did not prevent a TDC response to heat stress, but changed the response intensity. A long-term increase in JH titre had no effect on the activity of main OA catabolyzing enzyme, arylalkylamine N-acetyltransferase, in females of both species. A possible mechanism of regulation of OA levels by 20E and JH in Drosophila females is discussed.

摘要

在正常和热应激（38摄氏度）条件下，研究了外源20-羟基蜕皮激素（20E）和保幼激素（JH）对野生型粗壮果蝇和黑腹果蝇年轻雌性个体中章鱼胺（OA）合成的第一种酶——酪氨酸脱羧酶（TDC）活性的影响。喂食20E的果蝇在这两个物种中均表现出TDC活性增加。施用JH降低了这两个物种的TDC活性。JH和20E水平的升高并未阻止TDC对热应激的反应，但改变了反应强度。JH滴度的长期升高对这两个物种雌性个体中主要的OA分解代谢酶——芳基烷基胺N-乙酰基转移酶的活性没有影响。讨论了果蝇雌性个体中20E和JH调节OA水平的可能机制。