Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Lavrentieva Ave. #10, Novosibirsk, Russia.
Arch Insect Biochem Physiol. 2009 Dec;72(4):263-72. doi: 10.1002/arch.20337.
The effects of exogenous 20-hydroxyecdysone (20E) and the juvenile hormone (JH) on the activity of the tyrosine hydroxylase (TH), the first and rate-limiting DA biosynthetic enzyme, has been studied in young females of wild type D. virilis and D. melanogaster under normal conditions and under heat stress (38 degrees C). Both 20E feeding of the flies and JH application led to a substantial rise in TH activity. A rise in JH and 20E levels was found not to prevent the response of TH to heat stress, but to change the intensity of its response to the stress exposure. Putative mechanisms of regulation of DA level by 20E and JH in Drosophila females are discussed.
在正常条件和热应激（38 摄氏度）下，研究了外源 20-羟基蜕皮酮（20E）和保幼激素（JH）对年轻雌性野生型 D. virilis 和 D. melanogaster 酪氨酸羟化酶（TH）活性的影响，TH 是第一个限速 DA 生物合成酶。苍蝇的 20E 喂养和 JH 应用都导致 TH 活性的大幅上升。发现 JH 和 20E 水平的升高并不能阻止 TH 对热应激的反应，而是改变了其对应激暴露的反应强度。讨论了 20E 和 JH 调节果蝇雌蝇 DA 水平的可能机制。
