Irwin Debra E, Mungapen Laura, Milsom Ian, Kopp Zoe, Reeves Penny, Kelleher Con
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27516, USA.
BJU Int. 2009 Jan;103(2):202-9. doi: 10.1111/j.1464-410X.2008.08036.x.
To calculate up-to-date estimates of the economic impact of overactive bladder syndrome (OAB) with and without urgency urinary incontinence (UUI) on the health sector of six countries (Canada, Germany, Italy, Spain, Sweden and the UK), as OAB is a significant health concern for adults aged >18 years living in Western countries.
The prevalence data derived from the EPIC study were combined with healthcare resource-use data to derive current direct and indirect 1-year or annual cost of illness estimates for OAB including UUI in Canada, Germany, Italy, Spain, Sweden and the UK. This model estimates the direct healthcare costs attributed to OAB, as well as the impact of work absenteeism.
The estimated average annual direct cost of OAB per patient ranged between 262 in Spain and 619 in Sweden. The estimated total direct cost burden for OAB per country ranges between 333 million in Sweden and 1.2 billion in Germany and the total annual direct cost burden of OAB in these six countries is estimated at 3.9 billion. In addition, nursing home costs were estimated at 4.7 billion per year and it was estimated that work absenteeism related to OAB costs 1.1 billion per year.
The cost of illness for OAB is a substantial economic and human burden. This study may under-estimate the true economic burden, as not all costs for sequelae associated with OAB have been included. Cost-effective treatments and management strategies that can reduce the burden of OAB and in particular UUI have the potential to significantly reduce this economic burden.
计算伴有和不伴有急迫性尿失禁(UUI)的膀胱过度活动症(OAB)对六个国家(加拿大、德国、意大利、西班牙、瑞典和英国)卫生部门的最新经济影响估计值,因为OAB是生活在西方国家的18岁以上成年人的一个重大健康问题。
将来自EPIC研究的患病率数据与医疗资源使用数据相结合,得出加拿大、德国、意大利、西班牙、瑞典和英国OAB(包括UUI)当前的直接和间接1年或年度疾病成本估计值。该模型估计了归因于OAB的直接医疗成本以及旷工的影响。
每位患者OAB的估计平均年度直接成本在西班牙为262,在瑞典为619。每个国家OAB的估计直接成本负担在瑞典为3.33亿,在德国为12亿,这六个国家OAB的年度直接成本总负担估计为39亿。此外,疗养院成本估计每年为47亿,与OAB相关的旷工成本估计每年为11亿。
OAB的疾病成本是一项巨大的经济和人力负担。本研究可能低估了真正的经济负担,因为并非所有与OAB相关的后遗症成本都已包括在内。能够减轻OAB尤其是UUI负担的具有成本效益的治疗和管理策略有可能显著减轻这一经济负担。