KRAB/KAP1介导的组蛋白修饰对附加型基因表达的调控
Regulation of episomal gene expression by KRAB/KAP1-mediated histone modifications.
作者信息
Barde Isabelle, Laurenti Elisa, Verp Sonia, Groner Anna Claire, Towne Christopher, Padrun Viviane, Aebischer Patrick, Trumpp Andreas, Trono Didier
机构信息
School of Life Sciences, Frontiers in Genetics National Center for Competence in Research, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
出版信息
J Virol. 2009 Jun;83(11):5574-80. doi: 10.1128/JVI.00001-09. Epub 2009 Mar 11.
Abstract
KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator.
摘要
KAP1是KRAB锌指蛋白的一种重要辅助因子，KRAB锌指蛋白是脊椎动物特有的表观遗传抑制因子家族，其功能大多未知，在小鼠和人类基因组中有数百种编码。到目前为止，KRAB/KAP1介导的基因调控已在染色体DNA环境中进行了研究。在此，我们证明KRAB/KAP1调控在游离DNA的背景下，如腺相关病毒和非整合慢病毒载体中，具有完全功能，并且与通常与这种表观遗传调节因子相关的组蛋白修饰相关。
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