Multifaceted role of in health and disease.

The (tripartite motif) family, with as a key member, plays a vital role in regulating health and disease. contains various functional domains essential for transcriptional regulation, primarily through its interaction with proteins, which influence chromatin remodeling and gene expression. Despite extensive research, the precise mechanisms by which impacts health and disease remain elusive. This review delves into 's multifaceted roles in maintaining health, contributing to a variety of diseases, and influencing cancer progression. In cancers, exhibits a dual nature, functioning as both a tumor promoter and suppressor depending on the cellular context and cancer type. The review also explores its critical involvement in processes such as DNA repair, cell cycle regulation, epithelial-to-mesenchymal transition, and the maintenance of stem cell properties. By uncovering 's complex roles across different cancers and other diseases, this review underscores its potential as a therapeutic target. The significance of as a versatile regulator opens the door to innovative therapeutic strategies, particularly in cancer treatment and the management of other diseases. Ongoing research into may yield key insights into disease progression and novel treatment options.