Silverman Natalie E, Nicklas Barbara J, Ryan Alice S
University of Maryland School of Medicine, Geriatric Research, Education and Clinical Center of the Baltimore Veterans Affairs Medical Center, GRECC (BT/18/GR), 10 North Greene Street, Baltimore, MD 21201-1524, USA.
Calcif Tissue Int. 2009 Apr;84(4):257-65. doi: 10.1007/s00223-009-9232-z. Epub 2009 Mar 11.
Increased inflammation and weight loss are associated with a reduction in bone mineral density (BMD). Aerobic exercise may minimize the loss of bone and weight loss may contribute to a decrease in cytokines. We tested the hypothesis that aerobic exercise in combination with a weight loss program would decrease circulating concentrations of inflammatory markers, thus mediating changes in BMD. This was a nonrandomized controlled trial. Eighty-six overweight and obese postmenopausal women (50-70 years of age; BMI, 25-40 kg/m(2)) participated in a weight loss (WL; n = 40) or weight loss plus walking (WL + AEX; n = 46) program. Outcome measures included BMD and bone mineral content of the femoral neck and lumbar spine measured by dual energy X-ray absorptiometry, interleukin-6, tumor necrosis factor-alpha, soluble receptors of IL-6, and TNF-alpha (sTNFR1 and sTNFR2; receptors in a subset of the population), VO(2) max, fat mass, and lean mass. Weight decreased in the WL (p < 0.001) and WL + AEX (p < 0.001) groups. VO(2) max increased (p < 0.001) after WL + AEX. There was a 2% increase in femoral neck BMD in the WL + AEX group (p = 0.001), which was significantly different from the WL group. The change in sTNFR1 was significantly associated with the change in femoral neck BMD (p < 0.05). The change in VO(2) max was an independent predictor of the change in femoral neck BMD. Our findings suggest that the addition of aerobic exercise is recommended to decrease inflammation and increase BMD during weight loss in overweight postmenopausal women.
炎症增加和体重减轻与骨矿物质密度（BMD）降低有关。有氧运动可能会减少骨质流失，而体重减轻可能有助于降低细胞因子水平。我们检验了这样一个假设，即有氧运动与减肥计划相结合会降低循环炎症标志物浓度，从而介导骨密度的变化。这是一项非随机对照试验。86名超重和肥胖的绝经后女性（年龄50 - 70岁；体重指数，25 - 40 kg/m²）参加了减肥（WL；n = 40）或减肥加步行（WL + AEX；n = 46）计划。结果测量指标包括通过双能X线吸收法测量的股骨颈和腰椎的骨密度和骨矿物质含量、白细胞介素 - 6、肿瘤坏死因子 - α、IL - 6的可溶性受体以及TNF - α（sTNFR1和sTNFR2；部分人群中的受体）、最大摄氧量、脂肪量和去脂体重。WL组（p < 0.001）和WL + AEX组（p < 0.001）体重均下降。WL + AEX后最大摄氧量增加（p < 0.001）。WL + AEX组股骨颈骨密度增加了2%（p = 0.001），与WL组有显著差异。sTNFR1的变化与股骨颈骨密度的变化显著相关（p < 0.05）。最大摄氧量的变化是股骨颈骨密度变化的独立预测因素。我们的研究结果表明，建议在超重绝经后女性减肥期间增加有氧运动以减少炎症并增加骨密度。
