Miyazaki Masashi, Tsumura Hiroshi, Wang Jeffrey C, Alanay Ahmet
Department of Orthopaedic Surgery, Oita University, Oita, 879-5593, Japan.
Eur Spine J. 2009 Jun;18(6):783-99. doi: 10.1007/s00586-009-0924-x. Epub 2009 Mar 12.
With the current advances in spinal surgery, an understanding of the precise biological mechanism of each bone substitute is necessary for inducing successful spinal fusion. In this review, the categories of bone substitutes include allografts, ceramics, demineralized bone matrix, osteoinductive factors, autogenous platelet concentrate, mesenchymal stem cells, and gene therapy. Further, clinical studies have been evaluated by their levels of evidence in order to elucidate the precise effect of the bone substitute employed and to establish clinical guidance. This article will review both clinical studies based on evidence and basic research in current advances in order to avoid as far as possible any chances of failure in the future and to understand cellular biology in novel technologies.
随着脊柱外科手术的当前进展，了解每种骨替代物的确切生物学机制对于诱导成功的脊柱融合是必要的。在本综述中，骨替代物的类别包括同种异体移植物、陶瓷、脱矿骨基质、骨诱导因子、自体血小板浓缩物、间充质干细胞和基因治疗。此外，已根据其证据水平对临床研究进行了评估，以阐明所采用骨替代物的确切效果并建立临床指导。本文将回顾基于证据的临床研究和当前进展中的基础研究，以尽可能避免未来任何失败的可能性，并了解新技术中的细胞生物学。
