新生儿脑病：低温治疗
Neonatal encephalopathy: treatment with hypothermia.
作者信息
Shankaran Seetha
机构信息
Department of Pediatrics, Wayne State University School of Medicine, Division of Neonatal-Perinatal Medicine, Children's Hospital of Michigan, Detroit, Michigan 48201, USA.
出版信息
J Neurotrauma. 2009 Mar;26(3):437-43. doi: 10.1089/neu.2008.0678.
Abstract
In this article, the role of hypothermia and neuroprotection for neonatal encephalopathy will be discussed. The incidence of encephalopathy due to hypoxia ischemia as well as the pathophysiology will be presented. The diagnosis of encephalopathy in full-term neonates will be discussed. The current management of brain injury that occurs with hypoxia ischemia and the role of hypothermia in preventing brain injury in fetal and neonatal animal models will be reviewed. The current data from randomized control trials of hypothermia as neuroprotection for full-term infants will be presented along with the results of meta-analyses of these trials. Lastly, the status of ongoing neonatal hypothermia trials will be summarized.
摘要
在本文中，将讨论低温疗法及神经保护对新生儿脑病的作用。将介绍缺氧缺血性脑病的发病率及病理生理学。将讨论足月儿脑病的诊断。将回顾目前对缺氧缺血所致脑损伤的处理方法，以及低温疗法在胎儿和新生儿动物模型中预防脑损伤的作用。将呈现低温疗法作为足月儿神经保护措施的随机对照试验的当前数据，以及这些试验的荟萃分析结果。最后，将总结正在进行的新生儿低温疗法试验的情况。
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