Flodin Mats, Larsson Anders
Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden.
Clin Biochem. 2009 Jun;42(9):873-6. doi: 10.1016/j.clinbiochem.2009.02.024. Epub 2009 Mar 10.
Glomerular filtration rate (GFR) is widely accepted as the best overall measure of kidney function. Cystatin C is a novel endogenous GFR marker that has been shown to be superior to creatinine for estimation of GFR in several studies. There is a need for cystatin C assays adapted to routine chemistry instrument to minimize turnaround times and allowing 24 h/day availability.
We have evaluated a new cystatin C assay developed for Architect cSystem (Abbott Laboratories, Abbott Park, IL, USA).
The cystatin C assay showed good agreement with the corresponding assay from Dade Behring (Deerfield, IL, USA). The assay has a very low total imprecision and a good linearity.
The new cystatin C assay is an interesting alternative to current cystatin C assays. On an Architect cSystem the assay can be performed with the same turnaround times and availability as creatinine.
肾小球滤过率（GFR）被广泛认为是评估肾功能的最佳综合指标。胱抑素C是一种新型内源性GFR标志物，多项研究表明，在估算GFR方面，它优于肌酐。需要一种适用于常规化学分析仪的胱抑素C检测方法，以尽量缩短周转时间并实现全天24小时随时可用。
我们评估了一种为雅培生化免疫分析系统（美国雅培公司，伊利诺伊州雅培公园）开发的新型胱抑素C检测方法。
该胱抑素C检测方法与美国达德拜灵公司（伊利诺伊州迪尔菲尔德）相应的检测方法结果高度一致。该检测方法总不精密度极低，线性良好。
新型胱抑素C检测方法是现有胱抑素C检测方法的一个有趣替代方案。在雅培生化免疫分析系统上，该检测方法的周转时间和可用性与肌酐检测相同。
