Valtonen Hanna M, Suominen Kirsi, Sokero Petteri, Mantere Outi, Arvilommi Petri, Leppämäki Sami, Isometsä Erkki T
Department of Mental Health and Alcohol Research, National Public Health Institute, Helsinki, Finland.
J Affect Disord. 2009 Nov;118(1-3):48-54. doi: 10.1016/j.jad.2009.02.008. Epub 2009 Mar 17.
Suicidal ideation indicates risk for suicidal acts. How different definitions and measures for suicidal ideation influence its prevalence, correlates and predictive validity among bipolar disorder (BD) patients is unknown.
Among the 191 BD patients in the Jorvi Bipolar Study (JoBS), suicidal ideation at baseline was measured using the Scale for Suicidal Ideation (SSI), Hamilton Depression Scale (HAM-D) item 3 and Beck Depression Inventory (BDI) item 9 and by asking whether patients had seriously considered suicide. The predictive value of different definitions of ideation on suicide attempts during a six-month follow-up was investigated.
Altogether 74% of patients had suicidal ideation as defined in at least one of the above-mentioned ways, but only 29% met the criteria for all ways; agreement between definitions ranged from low to moderate (kappa coefficient 0.15 to 0.70). The correlates of suicidal ideation overlapped, but were not identical. Of the measures investigated, a baseline SSI score >or=8 had the best combination of sensitivity (0.81) and specificity (0.69) and a positive predictive value (PPV) of 32% for an attempted suicide during follow-up.
All plausible measures for suicidal ideation could not be investigated.
Who is classified as having suicidal ideation depends strongly on the definition and means of measurement among BD patients. Different measures for ideation have the potential to cause inconsistency when correlates of suicidal ideation are investigated. For clinically predicting suicide attempts during the next few months, an SSI score >or=8 may best combine sensitivity and specificity.
自杀观念提示有自杀行为的风险。不同的自杀观念定义和测量方法如何影响双相情感障碍(BD)患者中其患病率、相关因素及预测效度尚不清楚。
在约尔维双相情感障碍研究(JoBS)的191例BD患者中,使用自杀观念量表(SSI)、汉密尔顿抑郁量表(HAM-D)第3项和贝克抑郁量表(BDI)第9项,以及询问患者是否曾认真考虑过自杀来测量基线时的自杀观念。研究了不同自杀观念定义对6个月随访期间自杀未遂的预测价值。
总共74%的患者至少以上述一种方式被定义为有自杀观念,但只有29%的患者符合所有方式的标准;各定义之间的一致性从低到中度(kappa系数0.15至0.70)。自杀观念的相关因素有重叠,但并不完全相同。在所研究的测量方法中,基线SSI评分≥8具有最佳的敏感性(0.81)和特异性(0.69)组合,对随访期间自杀未遂的阳性预测值(PPV)为32%。
无法研究所有合理的自杀观念测量方法。
在BD患者中,谁被归类为有自杀观念在很大程度上取决于定义和测量方法。当研究自杀观念的相关因素时,不同的测量方法可能会导致不一致。对于临床预测未来几个月的自杀未遂,SSI评分≥8可能在敏感性和特异性方面达到最佳组合。