Li Zhensheng, Qu Yang, Zhang Xingdong, Yang Bangcheng
Engineering Research Center in Biomaterials, Sichuan University, Chengdu, China.
Acta Biomater. 2009 Jul;5(6):2189-95. doi: 10.1016/j.actbio.2009.02.013. Epub 2009 Feb 14.
Piezoelectric BaTiO(3) was employed as a crystal growth inhibitor additive for the preparation of bioactive nano-titania ceramics in this study. It is found that the additive could significantly inhibit nano-titania ceramic crystal growth during the pressureless sintering process. This inhibitory ability has great effects on the mechanical properties and bioactivities of the nano-titania ceramics, making it possible to obtain bioactive nano-titania ceramics with mechanical properties analogous to human bone. In this study, the crystal grain sizes of the nano-titania ceramics ranged from 18 to 68nm and the particle sizes ranged from 187 to 580nm by changing the additive content from 1% to 20%. The elastic modulus of the nano-titania ceramics ranged from 6.2 to 10.6GPa, which is analogous to that of human bone, by adjusting the additive content. The piezoelectric properties of the additive also showed the enhancing effects on the bioactivity of the nano-titania ceramics, which made the osteoblasts proliferate faster on the nano-titania ceramics in cell culture experiments. It might be a potential way to prepare bioactive nano-titania ceramics with biomechanical compatibility by using BaTiO(3) as a crystal growth inhibitor.
本研究中，压电材料钛酸钡（BaTiO₃）被用作晶体生长抑制剂添加剂，用于制备生物活性纳米二氧化钛陶瓷。研究发现，该添加剂在无压烧结过程中能显著抑制纳米二氧化钛陶瓷晶体的生长。这种抑制能力对纳米二氧化钛陶瓷的力学性能和生物活性有很大影响，使得获得具有类似于人体骨骼力学性能的生物活性纳米二氧化钛陶瓷成为可能。在本研究中，通过将添加剂含量从1% 改变至20%，纳米二氧化钛陶瓷的晶粒尺寸在18至68纳米范围内，颗粒尺寸在187至580纳米范围内。通过调整添加剂含量，纳米二氧化钛陶瓷的弹性模量在6.2至10.6吉帕之间，这与人体骨骼的弹性模量类似。添加剂的压电性能对纳米二氧化钛陶瓷的生物活性也有增强作用，在细胞培养实验中，这使得成骨细胞在纳米二氧化钛陶瓷上增殖更快。使用BaTiO₃作为晶体生长抑制剂可能是制备具有生物力学相容性的生物活性纳米二氧化钛陶瓷的一种潜在方法。
