淋巴细胞表面调节与环核苷酸I.淋巴细胞帽形成过程中环磷酸腺苷与免疫球蛋白免疫荧光的拓扑相关性
Lymphocyte surface modulation and cyclic nucleotides I. Topographic correlation of cyclic adenosine 3':5'-monophosphate and immunoglobulin immunofluorescence during lymphocyte capping.
作者信息
Earp H S, Utsinger P D, Yount W J, Logue M, Steiner A L
出版信息
J Exp Med. 1977 Apr 1;145(4):1087-92. doi: 10.1084/jem.145.4.1087.
Abstract
The cross-linking of human peripheral lymphocyte surface Ig results in an early association of cyclic adenosine 3':5'-monophosphate (cAMP) and the cell surface Ig patches. Examination of the subsequent stages of cap formation reveals the continued relationship of cAMP and the clustered surface Ig. In addition, the generalized influx of calcium produced by the ionophore A-23187 disrupts human lymphocyte caps. During the process of cap dissolution cAMP is still associated with surface Ig. Therefore, it is hypothesized that the localized concentration of cyclic nucleotide and calcium ion regulates the movement of cell surface constituents by coordinating the function of the cell's contractile and structural elements.
摘要
人外周淋巴细胞表面免疫球蛋白（Ig）的交联导致环磷酸腺苷（cAMP）与细胞表面Ig斑的早期结合。对帽形成后续阶段的检查揭示了cAMP与聚集的表面Ig之间的持续关系。此外，离子载体A-23187产生的普遍钙内流会破坏人淋巴细胞帽。在帽溶解过程中，cAMP仍与表面Ig相关。因此，据推测，环核苷酸和钙离子的局部浓度通过协调细胞收缩和结构元件的功能来调节细胞表面成分的运动。
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