Webster A D, North M E, Newton C, Asherson G L
Clin Exp Immunol. 1980 May;40(2):351-7.
Normal levels of lymphocyte cyclic AMP were found in fourteen of fifteen patients with primary hypogammaglobulinaemia. One patient with adult-onset hypogammaglobulinaemia had low cyclic AMP levels with a very poor rise after prostaglandin E1 stimulation. Five of the patients had severely depressed thymidine uptake by their phytohaemagglutinin-stimulated lymphocytes but there was no significant difference between their lymphocyte cyclic AMP levels and those of patients with normal lymphocyte responses. Removal of monocytes from concanavalin A-stimulated lymphocyte cultures from three of these patients did not affect the severe depression of leucine uptake. These findings indicate that the depression of lymphocyte response to mitogens seen in some patients with late-onset primary hypogammaglobulinaemia is not due to raised levels of lymphocyte cyclic AMP; and not usually due to prostaglandins released by monocytes in the cultures.
在15例原发性低丙种球蛋白血症患者中，有14例淋巴细胞环磷酸腺苷（cAMP）水平正常。1例成人起病的低丙种球蛋白血症患者的环磷酸腺苷水平较低，在前列腺素E1刺激后升高甚微。5例患者经植物血凝素刺激的淋巴细胞对胸苷的摄取严重降低，但他们的淋巴细胞环磷酸腺苷水平与淋巴细胞反应正常的患者之间无显著差异。从其中3例患者的伴刀豆球蛋白A刺激的淋巴细胞培养物中去除单核细胞，并不影响亮氨酸摄取的严重降低。这些发现表明，在一些迟发性原发性低丙种球蛋白血症患者中所见的淋巴细胞对有丝分裂原反应的降低，并非由于淋巴细胞环磷酸腺苷水平升高；也通常不是由于培养物中单核细胞释放的前列腺素所致。
