Brown Geoffrey
Department of Biomedical Sciences, School of Infection, Inflammation, and Immunology, College of Medicine and Health, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Int J Mol Sci. 2025 Apr 3;26(7):3346. doi: 10.3390/ijms26073346.
By the mid-1960s, hematopoietic stem cells (HSCs) were well described. They generate perhaps the most complex array of functionally mature cells in an adult organism. HSCs and their descendants have been studied extensively, and findings have provided principles that have been applied to the development of many cell systems. However, there are uncertainties about the process of HSC development. They center around when and how HSCs become affiliated with a single-cell lineage. A longstanding view is that this occurs late in development and stepwise via a series of committed oligopotent progenitor cells, which eventually give rise to unipotent progenitors. A very different view is that lineage affiliation can occur as early as within HSCs, and the development of these cells to a mature end cell is then a continuous process. A key consideration is the extent to which lineage-affiliated HSCs self-renew to make a major contribution to hematopoiesis. This review examines the above aspects in relation to our understanding of hematopoiesis.
到20世纪60年代中期，造血干细胞（HSCs）已得到充分描述。它们能产生成年生物体内可能最为复杂的一系列功能成熟细胞。造血干细胞及其后代已得到广泛研究，研究结果提供了一些原则，这些原则已应用于许多细胞系统的发育研究。然而，造血干细胞发育过程仍存在一些不确定性。这些不确定性集中在造血干细胞何时以及如何与单一细胞谱系相关联。长期以来的观点是，这种关联发生在发育后期，并通过一系列定向的寡能祖细胞逐步进行，这些寡能祖细胞最终产生单能祖细胞。另一种截然不同的观点是，谱系关联可能早在造血干细胞内就已发生，然后这些细胞发育为成熟终末细胞是一个连续的过程。一个关键的考量因素是，与谱系相关的造血干细胞自我更新以对造血做出主要贡献的程度。本综述结合我们对造血的理解来探讨上述各个方面。
